Please select a number from 0 to 10 to reflect the severity of the symptom. 0 is absent/as good as it can be and 10 is worst-imaginable. Please ensure that every number selected can accurately reflect your condition.

	Symptom Severity
	Please rate your fatigue (weariness, tiredness) by choosing the one number that best describes your WORST level of fatigue during past 24 hours
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Choose the one number that describes how, during the past week how much difficulty you have had with each of the following symptoms
	Filling up quickly when you eat (early satiety)
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Abdominal discomfort
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Inactivity
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Problems with concentration (compared with before the diagnosis)
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Night sweats
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Itching (pruritis)
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Bone pain (widespread, not joint pain or arthritis)
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Fever (>37.8°C or >100°F)
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable
	Unintentional weight loss (in the last 6 months)
	0	1	2	3	4	5	6	7	8	9	10
	Absent					Worst-imaginable

MPN-SAF TSS items were designated as “moderate” if symptoms were rated as ≥ 4 of 10 or ≤ 6 of 10; and as “severe” if symptoms were rated as ≥ 7 of 10. For patients who completed at least six of these 10 items on the BFI and MPN-SAF, the MPN TSS was computed as the average of the observed items multiplied by 10 to achieve a 0-to-100 scale.

Additional information:

What are myeloproliferative neoplasms?

Myeloproliferative neoplasms include primary myelofibrosis (PMF), essential thrombocythaemia (ET) and polycythaemia vera (PV).²

Among them, primary myelofibrosis is a Philadelphia-negative classical MPN. This rare type of blood cancer is characterized by the overproduction of a specific type of blood cells in the body that disrupts the normal functioning of the body, resulting in scarring of the bone marrow (fibrosis) and spleen enlargement. Potential complications and symptoms include fatigue, fever, night sweats, itchy skin, bone pain, abdominal pain or discomfort, and weight loss.¹ Prognosis of myelofibrosis is poor and treatment options are limited.^3,4 About 10%-15% myelofibrosis cases begin with primary thrombocytosis or polycythemia. These cases are also known as secondary myelofibrosis.²