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Scoring System Calculator for prognosis of primary Myelofibrosis
MIPSS-70+ Version 2.0
Prognostic Variable
| Prognostic Variable | Answer |
|---|---|
| Severe anemia (hemoglobin <8 g/dL in women and <9 g/dL in men) | |
| Moderate anemia (hemoglobin 8–9.9 g/dL in women and 9–10.9 g/dL in men) | |
| Circulating Blast (%) | |
| Constitutional Symptoms | |
| Absence of CALR Type 1 Mutation | |
| High-molecular Risk (HMR) Mutations* * Presence of a mutation in any of the following genes: ASXL1, EZH2, SRSF2, U2AF1 Q157, or IDH1/2. |
|
| Number of HMR Mutations | |
| Unfavourable Karyotype** ** Unfavorable karyotype: complex karyotype or sole or two abnormalities that include trisomy 8, 7/7q-, i(17q), 5/5q-, 12p-, inv(3), or 11q23 rearrangement. |
|
| Very-high-risk (VHR) Karyotype*** *** VHR karyotype: single/multiple abnormalities of −7, i(17q), inv(3)/3q21, 12p−/12p11.2, 11q−/11q23, or other autosomal trisomies not including + 8/+9 (eg, +21, +19). |
|
MIPSS-70+ Version 2.0
Total Score 0
point
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MIPSS-70+ Version 2.0
Risk Group -
risk
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Estimated
Median Survival 0%
10-year OS rates
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References:
1. NCCN Practice Guidelines. Myeloproliferative Neoplasms. Version 2.2022
