Scoring System Calculator for prognosis of primary Myelofibrosis

MIPSS-70

Prognostic Variable

Prognostic Variable	Answer
Hemoglobin (g/dL)	≥10 <10
Leukocytes (x10⁹/L)	>25 ≤25
Platelets (x 10⁹/L)	≥100 <100
Circulating blasts (%)	≥2 <2
Bone marrow fibrosis grade	≥2 <2
Constitutional symptoms	No Yes
CALR type-1 unmutated genotype	No Yes
High-molecular risk (HMR) mutations	No Yes
Number of HMR mutations	≥2 <2

MIPSS-70
Total Score

point

MIPSS-70
Risk Group

risk

Estimated
Median Survival

5-year OS rates

*Presence of a mutation in any of the following genes: ASXL1, EZH2, SRSF2, or IDH1/2.

References:
NCCN Practice Guidelines. Myeloproliferative Neoplasms. Version 2.2022